Inventory reference ISSN 1812-7231 Klin.inform.telemed. Volume 12, Issue 13, 2017, Pages 92–104
Author(s) V. M. Sokolov1,2, O. S. Sitnikova4, G. M. Rozhkovskaya1, T. K. Dorofeyeva1, V. M. Tsvygovskiy1, M. O. Lyubchak3, L. V. Onishchenko1
Institution(s) 1Odessa Medical University, Ukraine 2Diagnostic centre "Yuzh-Ukrmedtekh", Odessa, Ukraine 3Clinical hospital "Odrex", Odessa, Ukraine 4Regional Clinical Hospital, Odessa, Ukraine
Article title Diffusion-weighted images and PET/CT in the diagnosis of cancer pathology of the abdominal cavity
Introduction. Analysis of literary sources devoted to the use of CT, DWI and PET/CT techniques for diagnosis of malignant abdominal cavities (stomach cancer, colon cancer, lumbar abdominal cavity etc.), are ambiguous and sometimes even controversial. Particularly, difficult is diagnosis of stomach cancer which remains the second most common cancer in the world.
The purpose of the work is to study the diagnostic possibility of the DWI method and compare it with the diagnostic characteristics of multi-spiral computed tomography (MCT) and 18F-FDG PET/CT in the diagnosis of malignant abdominal cavity forms.
Materials and methods. Intensity of the signal in the series of DWI was measured and the values of the diffusion coefficient (ADC) were calculated. DWI is based on the registration of changes in the nature of the Brownian motion of water molecules in various pathological processes. PET/CT was performed using a fluorine-18-deoxyglucose labeled radioactive isotope (FDG), a method that allows to visualize and to value quantitatively glucose metabolism in tumor tissues.
Results. The obtained results indicate DWI has a higher sensitivity, but shows lower specificity than 18F-FDG PET/CT. Typically, DWI is more efficient than 18F-FDG PET/CT for the preoperative diagnosis and is an additional visualization method, while 18F-FDG PET/CT has limited utility for preoperative formulation. Simultaneously, PET/CT provides a significant advantage in improving diagnosis routine, therapeutic monitoring of the patient, monitoring response to treatment.
Keywords Signal strength in a series of DWI, PET/CT, Evaluation of metabolism in tumor tissue.
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