DOI: https://doi.org/10.31071/kit2017.13.12

Inventory reference

ISSN 1812-7231 Klin.inform.telemed. Volume 12, Issue 13, 2017, Pages 92–104

Author(s)

V. M. Sokolov¹, ², O. S. Sitnikova⁴, G. M. Rozhkovskaya¹, T. K. Dorofeyeva¹, V. M. Tsvygovskiy¹, M. O. Lyubchak³, L. V. Onishchenko¹

Institution(s)

¹Odessa Medical University, Ukraine ²Diagnostic centre "Yuzh-Ukrmedtekh", Odessa, Ukraine ³Clinical hospital "Odrex", Odessa, Ukraine ⁴Regional Clinical Hospital, Odessa, Ukraine

Article title

Diffusion-weighted images and PET/CT in the diagnosis of cancer pathology of the abdominal cavity

Abstract (resume)

Introduction. Analysis of literary sources devoted to the use of CT, DWI and PET/CT techniques for diagnosis of malignant abdominal cavities (stomach cancer, colon cancer, lumbar abdominal cavity etc.), are ambiguous and sometimes even controversial. Particularly, difficult is diagnosis of stomach cancer which remains the second most common cancer in the world.

The purpose of the work is to study the diagnostic possibility of the DWI method and compare it with the diagnostic characteristics of multi-spiral computed tomography (MCT) and 18F-FDG PET/CT in the diagnosis of malignant abdominal cavity forms.

Materials and methods. Intensity of the signal in the series of DWI was measured and the values of the diffusion coefficient (ADC) were calculated. DWI is based on the registration of changes in the nature of the Brownian motion of water molecules in various pathological processes. PET/CT was performed using a fluorine-18-deoxyglucose labeled radioactive isotope (FDG), a method that allows to visualize and to value quantitatively glucose metabolism in tumor tissues.

Results. The obtained results indicate DWI has a higher sensitivity, but shows lower specificity than 18F-FDG PET/CT. Typically, DWI is more efficient than 18F-FDG PET/CT for the preoperative diagnosis and is an additional visualization method, while 18F-FDG PET/CT has limited utility for preoperative formulation. Simultaneously, PET/CT provides a significant advantage in improving diagnosis routine, therapeutic monitoring of the patient, monitoring response to treatment.

Keywords

Signal strength in a series of DWI, PET/CT, Evaluation of metabolism in tumor tissue.

References

1. Kotlyarov P. M., Sergeev N. I., Egorova E. V. Multispiral computed tomography colonography and virtual colonoscopy in the detection of colon formations. Russian Electronic Journal of Radiology, Moscow. 2016, pp. 44–45. (In Russ.)Journal of Radiology, Moscow. 2016, pp. 44–45. (in Russ.)ournal of Radiology

2. Rostovtseva T. M., Ananyeva N. I., Karmazanovskiy G. G., Vasilyev S. V., Smirnova E. V., Yehova R. V. Pre operational staging of colon cancer. Specialized protocol of MRT. Russian Electronic Journal of Radiology, Moscow. 2016, pp. 61–63. (in Russ.)

3. Sokolov V. N., Sitnikova E. S. DWI and PET/CT in the diagnosis of oncological pathology of the abdominal cavity. Russian Electronic Journal of Radiology, Moscow. 2016, pp. 53–54. (in Russ.)

4. Choi J. Y., Shim К. Н., Kim S. E., Jung H. K., Jung S. А., Yoo К. The clinical value of 18F-fluorodeoxyglucose uptake on positron emission tomography/computed tomography for predicting regional lymph node metastasis and non-curative surgery in primary gastric carcinoma. Korean J. Gastroenterol, 2014, vol. 64, iss. 6, pp. 340–347.
https://doi.org/10.4166/kjg.2014.64.6.340
PMid:25530585

5. De Potter T., Flamen P., Van Cutsem E. et al. Whole-body PET with FDG for the diagnosis of recurrent gastric cancer. Eur. J. Nucl. Med. Mol. Imaging, 2001, vol. 29, pp. 525–529.
https://doi.org/10.1007/s00259-001-0743-8
PMid:11914891

6. Hopkins S., Yang G. Y. FDG PET imaging in the staging and management of gastric cancer. J. Gastrointest. Oncol. 2011, vol. 2, iss. 1, pp. 39–44.

7. Joon S. L., Mi J. Y., Myeong-Jin K., Woo J. H., Mi-Suk P., Jin-Young Ch., Tae-Sung K., Jong D. L. Sung H. N., Ki W. K. CT and PET in stomach cancer: preoperative staging and monitoring of response to therapy. Radio Graphics, 2006, vol. 26, pp. 143–156.
https://doi.org/10.1148/rg.261055078
PMid:16418249

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