DOI: https://doi.org/10.31071/kit2021.17.03

Inventory reference

ISSN 1812-7231(print), ISSN 2786-5800 (Online) Klin. inform. telemed. Volume 16, Issue 17, 2021, Pages 28-41

Author(s)

A. G. Chernenko¹, O. Yu. Mayorov^{1, 2}, T. D. Nessonova¹, A. B. Prognimak¹

Institution(s)

¹Kharkiv Medical Academy of Postgraduate Education, Ukraine

^1,2Institute for Children and Adolescents Health Protection of the National Academy of Medical Sciences of Ukraine¹Kharkiv Medical Academy of Postgraduate Education, Ukraine^{1, 2}Institute for Children and Adolescents Health Protection of the National Academy of Medical Sciences of Ukraine

Article title

The study of the functional state of the brain in patients with episodic migraine according to spectral analysis of the EEG

Abstract (resume)

Introduction. Migraine is not just a headache, but a complex neurological disorder with different clinical manifestations.

The aim. To study the functional state of the brain in patients with episodic migraine according to EEG spectral analysis and find out how traditional clinical symptoms are associated with changes in the bioelectrical activity of certain areas of the cerebral cortex.

Materials and methods. The study included 26 patients with episodic migraine (mean age 37,65 ± 10,61 years). The diagnosis of migraine was established according to the criteria of the international classification of headache. The control group consisted of 11 clinically healthy individuals (mean age 35,28 ± 9,52 years).

The EEG was recorded using a 24-channel electroencephalograph (DX-systems®, Ukraine). A monopolar EEG recording was performed with a combined reference electrode in a state of calm wakefulness and a test with an intellectual load (reverse counting in the mind). EEG analysis was performed using the NeuroResearcher®InnovationSuite qEEG system (Mi&T Institute, Ukraine). Patients did not take drugs for preventive treatment. Clinical tests of episodic migraine were used: plasma CGRP peptide level; number of days with headache during 3 months; visual analog scale (VAS Pain); Neck disability index (NDI), presence of allodynia. Significance of differences was determined using the Wilcoxon-Mann-Whitney non-parametric «U» test. The Data Mining procedure (Feature Selection and Variable Screening) was carried out to determine the mutual influence of indicators (Statistica 13.0, license).

Results. Neurophysiological and pathophysiological interpretation of the results was carried out using the projection of EEG electrodes onto Brodmann’s cytoarchitectonic areas, which allows obtaining detailed information about possible clinical abnormali-ties of brain activity in patients with episodic migraine. Differences in the functional state of Brodmann’s areas, on which the EEG electrodes were located, were revealed in patients in the interictal period compared with clinically healthy individuals based on EEG spectral analysis. The predictors and the relationship of the state of certain areas of the brain (parameters of spectral analysis) with recognized clinical tests, traditionally used in the examination of patients with episodic migraine, were revealed. The quantitative parameters of each EEG range were obtained. They reflect disorders of cognitive and other cerebral activity, help to conduct a correct pathophysiological interpretation of the results of the choice of targeted treatment.

Keywords

episodic migraine, EEG spectral analysis, Brodmann areas.

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