DOI:

Inventory reference

ISSN 1812-7231 Klin.inform.telemed. Volume 16, Issue 17, 2021, Pages 00-00

Author(s)

V.A. Kirichenko, T.V. Kulbashevskaya, A.V. Pechenin, V.G. Sergeev

Institution(s)

National Aerospace University "KhAI", Kharkiv, Ukraine

Article title

Evaluation of endothelial function with increased patient pressure and drug exposure

Abstract (resume)

Introduction. The article continues the analysis of the methodology for studying the endothelial regulation of arterial vascular tone, based on the registration and processing of rheographic signals in a probe with endothelium-dependent vasodilation. The influence of the patient's high blood pressure and ongoing pharmacotherapy on the assessment of endothelial function is considered. The results obtained are demonstrated using the data of the ReoCom complex.

Purpose of work. Consideration of the effect of the patient's high blood pressure and ongoing pharmacotherapy on the assessment of endothelial function. Finding opportunities to neutralize the influence of these factors on the accuracy of the proposed method for assessing endothelial function.

Research results. A method for neutralizing the effect of high blood pressure in a patient and ongoing pharmacotherapy on the result of assessing endothelial function has been proposed and substantiated. Experimental data have been obtained confirming the efficiency of the proposed solutions and demonstrating the advantages of the rheographic method for assessing endothelial function.

Conclusions. Compared to the classical D. Celermajer method, the proposed rheographic method for assessing endothelial function provides an increase in the measurement accuracy and simplification of the research methodology, makes it possible to implement screening examinations of the population and control the course of patient treatment, reduces the cost of the equipment used and the requirements for the qualifications of specialists conducting the examination.

Keywords

assessment of endothelial function, rheographic data, sources of error, blood pressure, reactive hyperemia, D. Celermajer method, the working point of endothelial regulation

References

1. Celermajer D.S., Sorensen K.E., Gooch V.M. et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet, 1992, vol. 340, pp.1111-1115.

2. Bataeva Yu., Kirichenko V., Kiselgov Ye., Kulbashevsky V., Sergeev V. Endothelial regulation of vascular tone study. Vestnik epileptologii [Epileptology Bulletin]. 2015, iss.1 (43-44), pp.15-48.

3. Bataeva Yu., Kirichenko V., Kiselgov Ye., Kulbashevsky V., Sergeev V. Endothelial regulation of vascular tone study (part 2). Vestnik epileptologii [Epileptology Bulletin].2016, iss. 1 (45-46), pp.3-33.

4. Bataeva Yu., Kirichenko V., Kiselgov Ye., Kulbashevsky V., Sergeev V. The choice of information parameters for the rheographic assessment of endothelial function in the reactive hyperemia probe. Vestnik epileptologii [Epileptology Bulletin]. 2017, iss. 1 (47-48), pp.3-18.

5. Bataeva Yu., Kirichenko V., Kulbashevsky V., Sergeev V. D.Celermajer method and its possibilities in endothelial function assessing. Klin.inform.telemed. ISSN 1812-7231 [Clinical informatics and telemedicine]. 2017, vol.12, iss. 13, pp.64–69.
https://doi.org/10.31071/kit2017.13.08

6. Bataeva Yu., Kirichenko V., KulbashevskayaT., Sergeev V. Evaluation of endothelial function using reographical data. Klin.inform.telemed. ISSN 1812-7231 [Clinical informatics and telemedicine]. 2018, vol. 13, is. 14, pp. 19–27.
https://doi.org/10.31071/kit2018.14.02

7. Bataeva Yu., Kirichenko V., Kulbashevskaya T., Sergeev V. Assessment of endothelial function taking into account the position of the endothelial regulation working point. Klin.inform.telemed. ISSN 1812-7231 [Clinical informatics and telemedicine]. 2019, vol. 14, iss. 15, pp. 74-87.
https://doi.org/10.31071/kit2019.15.07

8. Nebieridze D.V. Clinical significance of endothelial dysfunction in arterial hypertension. Sistemnyye gipertenzii [Systemic Hypertension], 2005, vol. 2, is. 1, pp. 31-38.
https://doi.org/10.26442/SG28739

9. Zateyshchikova A., Zateyshchikov D. Endothelial regulation of vascular tone: research methods and clinical significance. Kardiologiya [Cardiology], 1998, iss. 9, pp. 68-78.

10. Rogoza A., Balakhonova T., Chikhladze N., at al. Modern methods for assessing the state of blood vessels in patients with arterial hypertension: A guide for practicing physicians. Moscow, Izdatel'skiy dom "ATMOSFERA", 2008, 71 p. (In Russ.).

11. Sergeev V., Kiselgov Ye. Assessment of the state of the vascular system based on the results of rheographic measurements. Vestnik epileptologii [Epileptology Bulletin]. 2007, iss.1 (19-20), pp. 49-62.

12. Lupinskaya Z., Zarifyan A., Gurovich T., Schleifer S. Endoteliy. Funktsiya i disfunktsiya [Endothelium. Function and dysfunction]. Bishkek, KRSU Publ., 2008, 373 p. (In Russ.).

13. Caro K., Pedley T., Shroter R., Sid U. Mekhanika krovoobrashcheniya [Mechanics of blood circulation]. Moscow, Mir Publ, 1978, 624 p. (In Russ.).

14. Deanfield J., Donald A., Fern C. et al. Endothelial function and dysfunction. Part 1: Methodological issue s for assessment in the different vascular beds: A statement ву the Working group on Endothelin and Endothelial Factors of the European Society of Hypertension. J. Hypertension, 2005, vol.23 (1), pp. 7-17.

15. Sorensen K.Е., Celermajer D.S, Spiegelhalter D. et al. Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility. Br Heart J. 1995, vol. 74, pp. 247-253.

16. Corretti M.C., Anderson T.J., Benjamin E.J. et. al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery. A report of the International Brachial Artery Reactivity Task Force. J. Am. Coll. Cardiol. 2002, vol. 39, pp. 257-265.

17. Sergeev V., Kirichenko V., Kiselgov Ye., Kulbashevsky V. AD v simmetrichnykh sosudistykh basceynakh [BP in symmetric vascular basins]. Vestnik epileptologii [Epileptology Bulletin], 2013, iss. 1 (39-40), pp. 68-81.

18. Hilchenko G. (RU), Sergeev V.(UA), Kirichenko V.(UA), Kiselgov Ye.(UA), Kulbashevsky V.(UA). Blood pressure measurement method. Patent RU 2 013 1131 38A. Published by 10.2016.

19. Bataeva Yu., Kirichenko V., Kulbashevskaya T., Sergeev V. Blood pressure measurement method. Patent UA № 120800. Published by 10.02 2020.

Full-text version