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ISSN 1812-7231 Klin.inform.telemed. Volume 11, Issue 12, 2015, Pages 31–42


O. Yu. Mayorov


Institute for Medical Informatics and Telemedicine LTD, Kharkiv, Ukraine

Kharkiv Medical Academy of Postgraduate Education, Ministry of Healthcare of Ukraine

Institute of Children and Adolescents Health protection NAMS of Ukraine, Kharkiv

Article title

Quantitative assessment of the "neuroendocrine axes" and immune system in the setting of the experimental emotional stress (factor model)

Abstract (resume)

Introduction: The state of the "neuroendocrine stress axes", which are closely coordinated with the immune system, constitutes an essential element of the visceral component of resistance to stress. Interaction of three main "neuroendocrine stress axes" plays an important role in the general adaptation syndrome. Classical stress manifestation is a weight change of certain endocrine glands and components of the thymus and lymphatic system.

The purpose of the work is to create a model that can assess the state of the "neuroendocrine axes" and immune system in the setting of experimental emotional stress.

Objects and Methodology: Ninety four (94) outbred adult white male rats were involved into the study. During 5 days, the realistic modeling of the experimental emotional stress (modified model of 'anticipation stress') was carried out.

Results: The model of endocrine interactions in the setting of emotional stress has been developed. Comprehensive physiological interpretation of the following main factors has been done. F1 reflects the state of the multi-level 'hypothalamic-pituitary-adrenal axis' ('adrenocortical axis') under stress, F2 is a factor which reflects the resulting effect of the hormonal metabolic reorganization (metabolic effect of the adrenal cortex), F3 reflects the state of the immune system. The developed model allows revealing and quantitatively estimating the neuroendocrine level of the visceral component of resistance to emotional stress, and classifying animals depending on this level in objective manner


emotional stress, resistance to stress, "neuroendocrine stress axes", immune system, modeling of experimental stress, factor analysis


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