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ISSN 1812-7231 Klin.inform.telemed. Volume 11, Issue 12, 2015, Pages 26–30


V. P. Martsenyuk, A. S. Sverstyuk, O. M. Kuchvara


I. Ya. Horbachevsky Ternopil State Medical University, Ukraine

Article title

Exercise of optimal control of annealing stage оf polymerase chain reaction

Abstract (resume)

The general methodology of optimal control for obtaining the solution of the exercise of optimal flow on the annealing stage in the polymerase chain reaction is examined. Pontryagin's maximum principle to the exercise of optimal control is applied and the necessary condition of optimality is formulated. The results are useful for the numerical calculation of optimal control under the examined stage and help to minimize the required time of annealing stage implementation


polymerase chain reaction, annealing stage, optimal control, Pontryagin's maximum principle


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